Medical Articles 2/5

Posted by rob on February 5, 2007 under Uncategorized | Be the First to Comment

Reduced expression of FLIP(SHORT) in bone marrow of low risk myelodysplastic syndrome.
Synchronous occurrence of Philadelphia chromosome-positive chronic myelogenous leukemia and breast cancer.
The
farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of
the MDR1 gene product, P-glycoprotein, and demonstrates significant
cytotoxic synergism against human leukemia cell lines.
The
tyrosine-kinase inhibitor imatinib induces long-term remission in a
patient with chronic myelogenous leukemia with translocation t(4;22).
Novel compounds with antiproliferative activity against imatinib-resistant cell lines.
[The latest data on posaconazole.]
Pivanex,
a histone deacetylase inhibitor, induces changes in BCR-ABL expression
and when combined with STI571, acts synergistically in a chronic
myelocytic leukemia cell line.
A distinct epigenetic signature at targets of a leukemia protein.
Antiproliferative
and apoptotic effects of two new gold(III)
methylsarcosinedithiocarbamate derivatives on human acute myeloid
leukemia cells in vitro.
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