Posted by rob on April 24, 2009 under Uncategorized | 
Ocular side effects are very common complaints among patients receiving imatinib therapy, with up to 70% of patients experiencing mild to moderate periorbital edema at the doses of 400mg or higher. But the conjunctiva chemosis associated with imatinib mesylate is relatively rare . Here we report that severe conjunctival chemosis secondary to imatinib treatment can be managed by concomitant oral short-term steroid therapy without discontinuation of imatinib. (Source: Leukemia Research)
Posted by rob on under Uncategorized |
In this issue of Leukemia Research, Tavernier-Tardy and colleagues provide evidence that an “adhesive” phenotype of the leukemia cells, characterized by higher surface expression of CXCR4 chemokine receptors, VLA-4 integrins, and the focal adhesion kinase (FAK) is associated with poor outcome in patients with AML. As such, this report is in line with a series of pre-clinical and clinical reports that came out over the last few years (reviewed in ), highlighting the importance of the microenvironment in acute and chronic leukemias. Our current concepts about the microenvironment in leukemia imply that chemokine receptors and adhesion molecules, which normally work hand in hand during leukocyte trafficking , are also central players in leukemia cell migration and homing to tissue niches …
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