[Chronic myeloid leukemia in the 21st century: biology and treatment]
Posted by rob on October 23, 2009 under Uncategorized | 
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[Chronic myeloid leukemia in the 21st century: biology and treatment]
Rev Invest Clin. 2009 May-Jun;61(3):221-32
Authors: Chávez-González MA, Ayala-Sánchez M, Mayani H
Chronic Myeloid Leukaemia (CML) is a clonal disease, originated at the level of Hematopoietic Stem Cells (HSC) and characterized by the presence of the Philadelphia (Ph) chromosome and its oncogenic product p210(BcrAbl). Such a protein has been shown to be essential for malignant transformation, since it is capable of altering cell adhesion, proliferation and apoptosis. Historically, CML has been treated by using different approaches: arsenic (in the early days), a variety of chemical agents (busulfan, hydroxyurea, cytarabine), cytokines (IFN-alpha, IFNalpha-PEG), hematopoietic cell transplant (HCT), and more recently drugs generated by design (imatinib, nilotinib, dasatinib). All these molecules exert specific effects on HSC and lead to a variety of clinical and biological responses. In this article, we present an overview about hematopoiesis in CML and its implications in the treatment of this disease.
PMID: 19736811 [PubMed - indexed for MEDLINE]