Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies [Hematologic Malignancies]

Posted by rob on December 21, 2009 under Uncategorized | Comments are off for this article

Conclusion
Mutations in the Cbl family RING finger domain or linker sequence constitute important pathogenic lesions associated with not only preleukemic CMML, JMML, and other MPN, but also progression to AML, suggesting that impairment of degradation of activated tyrosine kinases constitutes an important cancer mechanism. (Source: Journal of Clinical Oncology)
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