DNA methylation does not regulate JUNB expression in CML: Comment on “Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia” by Hoshino et al. [Leuk. Res. 33 (2009) 1361–1366]

Posted by rob on March 31, 2010 under Uncategorized | Comments are off for this article

In a recent report in this journal Hoshino et al. reported that JUNB was not a target for frequent promoter methylation in CML, either in chronic phase or in blast crisis. These results were in stark contrast to a previous report of Yang et al. which had suggested that hypermethylation of JUNB was widespread in CML patients and was a major mechanism for downregulation of JUNB in CML blast crisis. Thus the role of methylation in regulating JUNB in CML remains controversial. (Source: Leukemia Research)
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