Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome.
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Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome.
BMC Med Genet. 2010;11:163
Authors: Ma W, Kantarjian H, Zhang K, Zhang X, Wang X, Chen C, Donahue AC, Zhang Z, Yeh CH, O’Brien S, Garcia-Manero G, Caporaso N, Landgren O, Albitar M
Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS.
PMID: 21078205 [PubMed - indexed for MEDLINE]