Three novel alternative splicing mutations in BCR?ABL1 detected in CML patients with resistance to kinase inhibitors

Posted by rob on February 5, 2011 under Uncategorized | Comments are off for this article

Conclusion:? These findings, when combined with the data on 35INS, support the concept that loss of the C?terminus of BCR?ABL1 is associated with significant resistance to kinase inhibitors; this mechanism appears to be a major source of resistance to kinase inhibitors. (Source: Clinical and Laboratory Haematology)
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