Three novel alternative splicing mutations in BCR-ABL1 detected in CML patients with resistance to kinase inhibitors.

Posted by rob on February 5, 2011 under Uncategorized | Comments are off for this article

Conclusion:? These findings, when combined with the data on 35INS, support the concept that loss of the C-terminus of BCR-ABL1 is associated with significant resistance to kinase inhibitors; this mechanism appears to be a major source of resistance to kinase inhibitors.
PMID: 21266020 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
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