Down?regulation of thanatos?associated protein 11 by BCR?ABL promotes CML cell proliferation through c?Myc expression

Posted by rob on March 13, 2011 under Uncategorized | Comments are off for this article

AbstractBcr?Abl activates various signaling pathways in chronic myelogenous leukemia (CML) cells. The proliferation of Bcr?Abl transformed cells is promoted by c?Myc through the activation of Akt, JAK2 and NF??B. However, the mechanism by which c?Myc regulates CML cell proliferation is unclear. In the present study, we investigated the role of thanatos?associated protein 11 (THAP11), which inhibits c?Myc transcription, in CML cell lines and in hematopoietic progenitor cells derived from CML patients. The induction of THAP11 expression by Abl kinase inhibitors in CML cell lines and in CML?derived hematopoietic progenitor cells resulted in the suppression of c?Myc. In addition, over?expression of THAP11 inhibited CML cell proliferation. In colony forming cells derived fr…
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