Posted by rob on April 23, 2011 under Uncategorized | 
A Model of Oscillatory Blood Cell Counts in Chronic Myelogenous Leukaemia.
Bull Math Biol. 2011 Apr 22;
Authors: Drobnjak I, Fowler AC
In certain blood diseases, oscillations are found in blood cell counts. Particularly, such oscillations are sometimes found in chronic myelogenous leukaemia, and then occur in all the derived blood cell types: red blood cells, white blood cells, and platelets. It has been suggested that such oscillations arise because of an instability in the pluri-potential stem cell population, associated with its regulatory control system. In this paper, we consider how such oscillations can arise in a model of competition between normal (S) and genetically altered abnormal (A) stem cells, as the latter population grows at the expense of the former. We use an analytic model of long period oscillations to describe regions of oscillatory behaviour in the S-A phase plane, and give parametric criteria to describe when such oscillations will occur. We also describe a mechanism which can explain dynamically how the transformation from chronic phase to acute phase and blast crisis can occur.
PMID: 21512833 [PubMed - as supplied by publisher]
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Interferon-induced sarcoidosis with osseous involvement in a patient with melanoma.
Hell J Nucl Med. 2011 Jan-Apr;14(1):68-69
Authors: Meristoudis G, Tsaroucha A, Ilias I, Giannakopoulos V, Batsakis C, Christakopoulou J
To the Editor: Interferons are widely used in the treatment of both malignant and nonmalignant diseases. One rare complication, attributable to the immunomodulatory effect of interferon (IFN) treatment is the triggering or exacerbation of sarcoidosis. We present the scintigraphic and radiographic imaging findings of a patient that developed sarcoidosis with bone involvement mimicking metastatic disease during the course of adjuvant IFN-alpha treatment for malignant melanoma. A 32 years old woman was diagnosed with a superficial left tibial melanoma, metastatic to the inguinal lymph nodes (Clark level IV; Breslow tumor thickness 1.82mm). Since the primary tumour had more than 0.75mm thickness the patient underwent re-excision of the primary lesion with radioguided sentinel lymph node biopsy, which was positive for micrometastases and subsequently underwent dissection of the lymph nodes of the left groin. She received adjuvant treatment with IFN-alpha. A chest X-ray taken prior to IFN-alpha treatment was unremarkable. Three months later, the patient presented with dry cough and mild dyspnea on exertion. Physical examination was unremarkable; a chest X-ray was inconclusive, with possible left hilar enlargement. Chest computed tomography (CT) showed enlarged mediastinal and hilar lymph nodes as well as a few bilateral small nodules. Pulmonary function tests showed normal spirometry, lung volumes were at lower limit of normal and diffusing capacity was moderately decreased at 79% of predicted. The patient was referred for a gallium-67 citrate ((67)Ga-C) scan, which showed the characteristic “Lambda sign” indicative of sarcoidosis as well as foci of increased accumulation in the right scapula and left iliac bone. A subsequent technetium-99m methylene diphosphonate ((99m)Tc-MDP) scan revealed the same skeletal lesions. Magnetic resonance imaging (MRI) of the thorax and pelvis was concordant with the (67)Ga-C and (99m)Tc-MDP scan findings. The patient’s history of malignant melanoma and the anatomical and functional imaging findings led to the clinical suspicion of osseous metastases. Bronchoaleolar lavage showed lymphocytosis, leukocytosis and macrophages with elevated CD4/CD8 ratio. Moreover, transbronchial needle aspiration lung biopsy revealed non-caseating granulomas whereas bone biopsy of the right scapula was negative for malignancy and showed non-caseating granulomas, consistent with sarcoidosis. Treatment with IFN-alpha was withdrawn; the dyspnea and dry cough subsided within several weeks and three months later the patient had complete clinical remission. Pulmonary function tests were normal and a follow-up MRI after 9 months showed resolution of both hilar lymphadenopathy and osseous lesions. The patient, six years after initial presentation, remains in clinical remission. Thus, a diagnosis of interferon-induced sarcoidosis in melanoma adjuvant treatment was established. It has been recently recognized that IFN-alpha can induce or exacerbate sarcoidosis, presumably through its ability to stimulate the T-helper cell type 1 immune response leading to granuloma formation, which is also involved in the pathogenesis of sarcoidosis, resulting in clinical disease in susceptible individuals. Reported IFN-alpha-induced sarcoidosis occurs from 2 to 168 weeks after starting treatment. The most common organs involved are the lungs, lymph nodes and the skin. After discontinuation of IFN-alpha, and with no other treatment received, the prognosis of sarcoidosis in the vast majority of cases is favourable; for some patients corticosteroids are needed. Most cases of IFN-induced sarcoidosis have been described in patients treated with IFN for chronic hepatitis C; sarcoidosis has also been reported in patients treated with IFN for chronic hepatitis B, renal carcinoma, chronic myelogenous leukaemia, multiple sclerosis, multiple myeloma, and lymphoma. Eleven cases of sarcoidosis have been reported in IFN- treated patients with malignant melanoma. To the best of our knowledge IFN-induced sarcoidosis with bone involvement has not been reported previously. Scintigraphy with (67)Ga-C has the advantage of detecting both pulmonary, with the characteristic lambda and/or panda uptake pattern and extrapulmonary foci of sarcoidosis, assisting diagnosis. Biopsy is mandatory for the diagnosis of the disease. Among the newer functional imaging modalities, fluorine-18 fluoro-deoxyglucose ((18)F-FDG) PET is not useful in diagnosing sarcoidosis, since it shows nonspecific uptake, both pattern and intensity-wise, although it is useful in monitoring disease progression or remission. Although sarcoidosis is a systemic disease, osseous involvement, mostly in the small bones of the hands and feet is relatively uncommon, noted in 5% of patients, although extremes of 1% to 13% have been reported. In some cases sarcoidosis may mimic metastatic dissemination. Although bone scans and MRI are more sensitive than either radiographs or (67)Ga-C scintigraphy in the detection of osseous sarcoidosis, they are also non-specific. In conclusion treatment with IFN-alpha may induce sarcoidosis not only in the lung but also in the skeleton; when restaging patients with malignant diseases it may mimic metastatic bone disease leading to diagnostic pitfalls.
PMID: 21512671 [PubMed - as supplied by publisher]
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AbstractWith the advent of molecularly targeted therapies in the oncology clinic, previously fatal blood cancers have now become chronic diseases. Imatinib, a small molecule tyrosine kinase inhibitor that targets the BCR?ABL fusion protein, dramatically extends survival for patients with chronic myelogenous leukemia and has opened the flood gates for modern “personalized cancer medicine”. Rituximab, a monoclonal antibody with affinity for the CD20 antigen of B?lymphocytes, in an analogous fashion has revolutionized treatment for patients with B?cell lymphomas. Does this paradigm, a rather commonplace approach for the treatment of hematologic malignancies, apply also to acute myelogenous leukemia (AML)? This is an exciting time to be involved in AML research, and an explosion of n…
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AbstractAichberger and colleagues recently described an association between nilotinib therapy for chronic myelogenous leukemia (CML) and adverse vascular events, which occurred in 8 (?33%) of their 24 CML patients treated with nilotinib: severe peripheral artery disease (PAD; n=3), less severe PAD (n=1), sudden death (n=1), myocardial infarction (n=1), spinal infarction (n=1) and subdural hematoma (n=1).1 We were intrigued by these observations because of similar events that occurred in two of our patients receiving nilotinib therapy. A female patient developed severe and unrelenting PAD and coronory artery disease (CAD) after approximately 3 years of treatment with nilotinib and the second patient died suddenly after receiving nilotinib therapy for 3 weeks. None of the two patients had …
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