Imatinib found to be effective in children with previously untreated chronic myelogenous leukaemia in early chronic phase

Posted by rob on July 31, 2011 under Uncategorized | Comments are off for this article

Source: J Clin Oncol
Area: News
This French prospective study evaluated the use of imatinib in children and adolescents with chronic myeloid leukemia (CML) in the chronic phase (CP).  Imatinib is used as standard care in adults with this condition, however, few data exist in children. Children age 0 to 18 years with previously untreated Philadelphia (Ph) chromosome positive CML in CP diagnosed within 2 months were eligible for entry. The study protocol permitted prior therapy with hydroxyurea (HU). Between March 2004 and December 2008, 44 patients were enrolled from16 academic hospitals in France. Study participants received imatinib 260 mg/m2 (maximum 400 mg) orally once daily. The primary objective of the study was to determine the progression-free survival (PFS) rate (defined as t…
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