Cas?L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl

Posted by rob on September 30, 2011 under Uncategorized | Comments are off for this article

AbstractThe p210Bcr/Abl and p190Bcr/Abl fusion oncoproteins are known to cause chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Bcr/Abl phosphorylates several proteins that can lead to leukemogenesis. The lymphocyte?type Cas family protein Cas?L (Crk?associated substrate lymphocyte type)/HEF1/NEDD9 is an adapter protein at focal adhesions known to be associated with solid tumor metastasis, and Cas?L has been reported to be tyrosine?phosphorylated by p190Bcr/Abl. We demonstrated that Cas?L was expressed in murine granulocytes as well as in lymphocytes and that Cas?L?deficient granulocytes had increased migratory activity and decreased adhesiveness. To examine whether Cas?L was involved in leukemogenesis by p210Bcr/Abl, we generated Cas?L?defic…
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