Crk?associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl

Posted by rob on September 30, 2011 under Uncategorized | Comments are off for this article

The p210Bcr/Abl and p190Bcr/Abl fusion oncoproteins are known to cause chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Bcr/Abl phosphorylates several proteins that can lead to leukemogenesis. Crk?associated substrate lymphocyte type (Cas?L)/human enhancer of filamentation?1 (HEF1)/neural precursor cell expressed, developmentally down?regulated 9 (NEDD9) is an adapter protein at focal adhesions known to be associated with solid tumor metastasis. Crk?associated substrate lymphocyte type has also been reported to be tyrosine phosphorylated by p190Bcr/Abl. We demonstrated that Cas?L was expressed in murine granulocytes, as well as in lymphocytes, and that Cas?L?deficient (Cas?L?/?) granulocytes had increased migratory activity and decreased adhe…
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