Fluorescent in situ hybridization diagnosis of extramedullary nodal blast crisis

Posted by rob on September 30, 2011 under Uncategorized | Comments are off for this article

In conclusion, this case is unusual at three levels: first, extramedullary nodal BC as a presenting manifestation of CML is rare and the blasts are of precursor T lymphoblastic lineage, rather than the more common B?cell lineage; second, this case suggests that extramedullary lymphoid nodal BC of CML can exist independently without the bone marrow developing into BC; and third, FISH analysis on the single neoplastic cell is an accurate way to confirm that the neoplasm is either extramedullary localized blasts of CML or genetically distinct neoplasm. Diagn. Cytopathol. 2011;. © 2011 Wiley?Liss, Inc. (Source: Diagnostic Cytopathology)
More