A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph+ chronic myeloid leukemia

Posted by rob on January 9, 2012 under Uncategorized | Comments are off for this article

Abstract  Chronic myelogenous leukemia (CML) is a common myeloproliferative disease that is characterized by the clonal expansion of
marrow stem cells, and is associated with the Philadelphia chromosome. As the disease progresses, additional chromosome abnormalities may arise. The prognostic impact of secondary
chromosomal abnormalities in CML is complex, heterogeneous, and sometimes related to previous treatment. Here, we describe
a CML patient in lymphoid blast crisis associated with a new chromosomal abnormality identified, dic(7;12)(p12.21;p12.2) and
i(12)(q10) using classical cytogenetics and spectral karyotype analysis. To the best of our knowledge, this is the first report
of t(7;12)(p11.1;q11.1) and i(12)(q10) in a CML patient with lymphoid evolution.

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