Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia

Posted by rob on January 9, 2012 under Uncategorized | Comments are off for this article

CONCLUSIONS:BCR?ABL1 expression up?regulated HO?1, a survival factor for CML cells. This up?regulation was more pronounced in blast crisis CML relative to early stage disease and was mediated by the NADPH oxidase components Rac1 and p47phox. The expression of p47phox was increased in BCR?ABL1–expressing cells. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)
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